Effect of propylene glycol on diclofenac permeation from compounded preparations: an in vitro Strat-M® membrane study
DOI:
https://doi.org/10.18690/analipazuhd.12.1-2.%25p.2026Keywords:
diclofenac sodium, in vitro permeation, Strat-M® membrane, propylene glycol, compounded preparationsAbstract
The aim of the study was to evaluate the effect of propylene glycol as a permeation enhancer on the permeation of diclofenac sodium from two compounded formulations through a Strat-M® synthetic membrane under in vitro conditions. Two Pentravan®-based formulations were investigated: one without enhancer and one containing 24% (w/w) propylene glycol. Permeation was assessed using Franz diffusion cells and UV-Vis spectrophotometry. The formulation containing propylene glycol showed higher diclofenac concentrations, greater cumulative permeation, and a higher fraction of permeated drug. Differences became more pronounced over time. The results confirm that propylene glycol enhances diclofenac permeation and highlight the importance of rational formulation design in topical preparations.
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