1-(6-O-Acetyl-3,4-Dideoxy-3-Fluoro-β-D-Glycero-Hex-3-enopyranosyl-2- Ulose)-N4-Benzoyl Cytosine is a potent inhibitor of pseudorabies virus replication in infected cells

1-(6-O-Acetil-3,4-Dideoksi-3-Fluoro-β-D-Glicero-Hex-3-enopiranozil-2- Uloza)-N4-Benzoil Citozin je močan inhibitor replikacije pseudorabies virusa v okuženih celicah

Authors

  • Botić Tanja University of Maribor, Faculty of Agriculture, Department of Microbiology, Biochemistry and Biotechnology, Slovenia Author
  • Stella Manta University of Thessaly, Department of Biochemistry and Biotechnology, Laboratory of Organic Chemistry, Greece Author
  • Dimitri Komiotis University of Thessaly, Department of Biochemistry and Biotechnology, Laboratory of Organic Chemistry, Greece Author
  • Francois Lefevre Unite de Virologie et Immunologie Moleculaires, France Author
  • Avrelija Cencič University of Maribor, Faculty of Agriculture, Department of Microbiology, Biochemistry and Biotechnology, Slovenia; Faculty of Medicine University of Maribor, Department of Biochemistry, Slovenia Author

DOI:

https://doi.org/10.18690/actabiomed.21

Abstract

Purpose: We have previously shown that newly synthesized fluoro-glucopyranosyl derivatives of ketonucleosides represent a group of antiviral drugs potent against RNA viruses. The aim of the present study was to ascertain whether these compounds are equally efficient in combating DNA viruses in comparison with the commercially available drug ganciclovir.

Methods: As a study model, the pseudorabies virus (NIA3 strain) and pig kidney cells (PK-15) were used.

Results: Our results indicated that 1-(6-O-acetyl-3,4-dideoxy-3-fluoro-β-D-glycero-hex-3-enopyranosyl-2-ulose)-N4-benzoyl cytosine (compound 2) is a potent inhibitor of pseudorabies replication, with higher antiviral activity than was found for ganciclovir.

Conclusion: Compound 2 has strong antiviral activity against the DNA virus pseudorabies.

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Author Biographies

  • Botić Tanja , University of Maribor, Faculty of Agriculture, Department of Microbiology, Biochemistry and Biotechnology, Slovenia

    Pivola, Hoče.

  • Avrelija Cencič, University of Maribor, Faculty of Agriculture, Department of Microbiology, Biochemistry and Biotechnology, Slovenia; Faculty of Medicine University of Maribor, Department of Biochemistry, Slovenia

    Prof. Avrelija Cenci; Maribor, Slovenia. E-mail: avrelija.cencic@uni-mb.si

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Published

23.10.2021

Issue

Vol. 2 No. 02 (2009)

Section

Articles

License

Copyright (c) 2009 Acta Medico-Biotechnica

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

Tanja , B., Manta, S. ., Komiotis, D. ., Lefevre, F. ., & Cencič, A. . (2021). 1-(6-O-Acetyl-3,4-Dideoxy-3-Fluoro-β-D-Glycero-Hex-3-enopyranosyl-2- Ulose)-N4-Benzoyl Cytosine is a potent inhibitor of pseudorabies virus replication in infected cells: 1-(6-O-Acetil-3,4-Dideoksi-3-Fluoro-β-D-Glicero-Hex-3-enopiranozil-2- Uloza)-N4-Benzoil Citozin je močan inhibitor replikacije pseudorabies virusa v okuženih celicah. Acta Medico-Biotechnica, 2(02), 41-47. https://doi.org/10.18690/actabiomed.21