1-(6-O-Acetyl-3,4-Dideoxy-3-Fluoro-β-D-Glycero-Hex-3-enopyranosyl-2- Ulose)-N4-Benzoyl Cytosine is a potent inhibitor of pseudorabies virus replication in infected cells

1-(6-O-Acetil-3,4-Dideoksi-3-Fluoro-β-D-Glicero-Hex-3-enopiranozil-2- Uloza)-N4-Benzoil Citozin je močan inhibitor replikacije pseudorabies virusa v okuženih celicah

  • Botić Tanja University of Maribor, Faculty of Agriculture, Department of Microbiology, Biochemistry and Biotechnology, Slovenia
  • Stella Manta University of Thessaly, Department of Biochemistry and Biotechnology, Laboratory of Organic Chemistry, Greece
  • Dimitri Komiotis University of Thessaly, Department of Biochemistry and Biotechnology, Laboratory of Organic Chemistry, Greece
  • Francois Lefevre Unite de Virologie et Immunologie Moleculaires, France
  • Avrelija Cencič University of Maribor, Faculty of Agriculture, Department of Microbiology, Biochemistry and Biotechnology, Slovenia; Faculty of Medicine University of Maribor, Department of Biochemistry, Slovenia
DOI: https://doi.org/10.18690/actabiomed.21

Abstract

Purpose: We have previously shown that newly synthesized fluoro-glucopyranosyl derivatives of ketonucleosides represent a group of antiviral drugs potent against RNA viruses. The aim of the present study was to ascertain whether these compounds are equally efficient in combating DNA viruses in comparison with the commercially available drug ganciclovir.

Methods: As a study model, the pseudorabies virus (NIA3 strain) and pig kidney cells (PK-15) were used.

Results: Our results indicated that 1-(6-O-acetyl-3,4-dideoxy-3-fluoro-β-D-glycero-hex-3-enopyranosyl-2-ulose)-N4-benzoyl cytosine (compound 2) is a potent inhibitor of pseudorabies replication, with higher antiviral activity than was found for ganciclovir.

Conclusion: Compound 2 has strong antiviral activity against the DNA virus pseudorabies.

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Author Biographies

Botić Tanja , University of Maribor, Faculty of Agriculture, Department of Microbiology, Biochemistry and Biotechnology, Slovenia

Pivola, Hoče.

Avrelija Cencič, University of Maribor, Faculty of Agriculture, Department of Microbiology, Biochemistry and Biotechnology, Slovenia; Faculty of Medicine University of Maribor, Department of Biochemistry, Slovenia

Prof. Avrelija Cenci; Maribor, Slovenia. E-mail: avrelija.cencic@uni-mb.si

Published
2021-10-23
How to Cite
Tanja B., Manta S., Komiotis D., Lefevre F., & Cencič A. (2021). 1-(6-O-Acetyl-3,4-Dideoxy-3-Fluoro-β-D-Glycero-Hex-3-enopyranosyl-2- Ulose)-N4-Benzoyl Cytosine is a potent inhibitor of pseudorabies virus replication in infected cells. Acta Medico-Biotechnica, 2(02), 41-47. https://doi.org/10.18690/actabiomed.21
Issue
Vol 2 No 02 (2009)
Section
Articles

Copyright (c) 2009 Acta Medico-Biotechnica

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