Supercritical fluids for the isolation and formulation of bioactive substances

Superkritični fluidi za izolacijo in formulacijo bioaktivnih snovi

  • Maša Knez Marevci 1University of Maribor, Faculty of Chemistry and Chemical Engineering, Laboratory of Separation Processes and Product Design
  • Katja Andrina Kravanja University of Maribor, Faculty of Chemistry and Chemical Engineering, Laboratory of Separation Processes and Product Design
  • Željko Knez University of Maribor, Faculty of Chemistry and Chemical Engineering, Laboratory of Separation Processes and Product Design; University of Maribor, Faculty of Medicine
Keywords: supercritical fluids, extraction, micronization, impregnation, deposition, sterilization

Abstract

Technologies involving sub- and supercritical fluids offer the possibility to obtain new products with special characteristics, which are especially needed in the pharmaceutical industry. The use of sub- or supercritical fluids for processing can also address legal limits for solvent residues and restrictions on the use of conventional solvents, while enabling new processes that are environmentally friendly and sustainable. Extraction of substances from plant materials, their in situ formulation in products with specific properties, particle formation, foaming, deposition, and sterilization have attracted much attention among the applications of supercritical fluids. This short overview reports the current status and expected future developments of research into sub- and supercritical fluid technologies.

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Author Biographies

Maša Knez Marevci, 1University of Maribor, Faculty of Chemistry and Chemical Engineering, Laboratory of Separation Processes and Product Design

Maribor, Slovenia.

Katja Andrina Kravanja, University of Maribor, Faculty of Chemistry and Chemical Engineering, Laboratory of Separation Processes and Product Design

Maribor, Slovenia.

Željko Knez, University of Maribor, Faculty of Chemistry and Chemical Engineering, Laboratory of Separation Processes and Product Design; University of Maribor, Faculty of Medicine

Maribor, Slovenia.

Published
2024-07-11
How to Cite
Knez Marevci M., Andrina Kravanja K., & Knez Željko. (2024). Supercritical fluids for the isolation and formulation of bioactive substances. Acta Medico-Biotechnica, 17(1), 28-35. https://doi.org/10.18690/actabiomed.265
Section
Articles